Image of Brandon Davies

Brandon Davies, PhD
Principal Investigator

Regulation of lipid homeostasis has been the consistent theme of my scientific career. As an undergraduate at the University of Utah, I studied cholesterol trafficking. As a graduate student at Berkeley, I studied two transcription factors that regulated the synthesis of ergosterol (the yeast version of cholesterol), and then as a post-doc at UCLA I started my work on the role of endothelial cells in regulating triglyceride metabolism. I also like to eat lipids. Aside from lipids, I am a long time biker. Although moving to Iowa has reduced the amount of time I spend mountain biking, it has added additional climatic elements to my bike commute and allowed me to expand the temperature range in which I have successfully biked to lab (current range -24 degrees [-41 with windchill] to 110 degrees).

portrait of Sonja Smith

Sonja Smith
Research Assistant

Athira Anirudhan

Postdoctoral Scholar

portrait of Alex Dumas

Alex Dumas

Graduate Student

portrain of Vir Patel

Vir Patel

Undergraduate Student

Tommy Mouser

Undergraduate Student

Evelyn Asay

Undergraduate Student

Mitchell Smith

Undergraduate Student

Lab mascot

Atherosharkosis

Lab Mascot

Alumni

Research Associates

Shwetha

Shwetha Shetty
Research Assistant (2012-2025)

Shwetha Engineering in Biotechnology in India, then did M.S. from Stephen F. Austin State University. Before coming to Iowa she worked as a Research Associate at UTHSCT, Tyler, Texas and IPSEN Pharmaceuticals, MA. After leaving the lab, she took a job at IDT. My lab experience got me interested in gene expression and regulation. 

Shwetha's Davies Lab Publications

  • Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS. Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. J Biol Chem. 2015 May 8;290(19):11865–11877
  • Cushing EM, Chi X, Sylvers KL, Shetty SK, Potthoff MJ, Davies BSJ. Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. Mol Metab. 2017 Jun 19;6(8):809–818.
  • Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 2017 Oct;6(10):1137-1149.
  • Cushing EM, Sylvers KL, Chi X, Shetty SK, Davies BS. Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4–/–Gpihbp1–/– mice. J. Lipid Res. 2018 Jul 1;59(7):1230–1243
  • Shetty SK, Walzem RL, Davies BSJ. A novel NanoBiT-based assay monitors the interaction between lipoprotein lipase and GPIHBP1 in real time. J. Lipid Res. 2020 Apr;61, 546–559.
  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice. Scientific Reports 2021 11:7873.
  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Chronic high fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice. Am J Physiol Endocrinol Metab. 2021 Oct 1;321(4):E464-E478.
  • Spitler KM, Shetty SK, Davies BSJ. Effects of age and diet on triglyceride metabolism in mice. J Lipid Res. 2025 Jan;66(1):100706. PMCID: PMC11730548
  • Shetty SK, Sylvers-Davie KL, Davies BSJ. Chronic High-Fat Diet Feeding Reduces the Rate of Postprandial Triglyceride Absorption Independent of Intestinal ANGPTL4. J Lipid Res. 2026 Aug 14:101124. doi: 10.1016/j.jlr.2026.101124. Online ahead of print.

Postdocs

Kelli

Kelli Sylvers-Davie, PhD
Postdoctoral Fellow (2022-2024)

Kelli's Davies Lab Publications

  • Cushing EM, Chi X, Sylvers KL, Shetty SK, Potthoff MJ, Davies BSJ. Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. Mol Metab. 2017 Jun 19;6(8):809–818.
  • Cushing EM, Sylvers KL, Chi X, Shetty SK, Davies BS. Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4–/–Gpihbp1–/– mice. J. Lipid Res. 2018 Jul 1;59(7):1230–1243
  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice. Scientific Reports 2021 11:7873.
  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Chronic high fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice. Am J Physiol Endocrinol Metab. 2021 Oct 1;321(4):E464-E478.
  • Sylvers-Davie KL, Segura-Roman A, Salvi AM, Schache KJ, Davies BSJ. Angiopoietin-like 3 Inhibition of Endothelial Lipase Is Not Modulated by Angiopoietin-like 8. J. Lipid Res. 2021 Aug 27;62:100112
  • Sylvers-Davies KL and Davies BSJ. Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8. Am J Physiol Endocrinol Metab. 2021;321(4):E493-E508.
  • Sylvers-Davie KL, Bierstedt KC, Schnieders MJ, Davies BSJ. Endothelial Lipase Variant T111I Does Not Alter Inhibition by Angiopoietin-like Proteins. Sci. Rep. 2024 Feb 20; 14(1):4246. 
  • Walker SG, Chen YQ, Sylvers-Davie KL, Dou A, Zhen EY, Qian Y, Wen Y, Ehsani ME, Smith SA, Thapa R, Mercer MJ, Langmack L, Bhattarai BR, Ploug M, Konrad RJ, Davies BSJ. Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase. JCI Insight. 2025 Oct 28;e197827. PMID: 41148215
  • Shetty SK, Sylvers-Davie KL, Davies BSJ. Chronic High-Fat Diet Feeding Reduces the Rate of Postprandial Triglyceride Absorption Independent of Intestinal ANGPTL4. J Lipid Res. 2026 Aug 14:101124. doi: 10.1016/j.jlr.2026.101124. Online ahead of print.

 

Image of Kathryn Spitler

 

Kathryn Spitler, PhD
Postdoctoral Scholar (2017-2021)

Katie's Davies Lab Publications

  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice. Scientific Reports 2021 11:7873.
  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Chronic high fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice. Am J Physiol Endocrinol Metab. 2021 Oct 1;321(4):E464-E478.
  • Spitler KM and Davies BSJ. Aging and Plasma Triglyceride Metabolism. J Lipid Res. 2020;61:1161-1167

 

Graduate Students

Sydney

Sydney Walker

Graduate Student (2022-2026)

Sydney's Davies Lab Publications:

Walker SG, Chen YQ, Sylvers-Davie KL, Dou A, Zhen EY, Qian Y, Wen Y, Ehsani ME, Smith SA, Thapa R, Mercer MJ, Langmack L, Bhattarai BR, Ploug M, Konrad RJ, Davies BSJ. Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase. JCI Insight. 2025 Oct 28;e197827. PMID: 41148215

Image of Kelli Davie

Kelli Sylvers-Davie
Graduate Student (2017-2021)

A Minnesota native, Kelli graduated from the College of Saint Scholastica in Duluth, MN with a bachelors in Biochemistry and Biology. She joined the Biochemistry program at the University of Iowa in 2016 and officially joined the Davies lab in the spring of 2017. In 2021 she defended her thesis, " ". She then continued in the lab as a postdoctoral fellow (see above)

Kelli's Davies Lab Publications are listed above.

Photo of Allison (Xun) Chi

Allison (Xun) Chi
Graduate Student (2013-2017)

Two months after finishing her undergraduate degree in China in 2012, Allison came to Iowa to begin her graduate studies in the department of Biochemistry. She joined the Davies lab in the spring of 2013. In 2017 Allison defended her thesis, "Extracellular Regulation of LPL Activity by Angiopoietin-like Proteins" and became the first student to get her PhD from the Davies Lab. Allison then joined the lab of Steve Bensinger at UCLA for her postdoc.

Allison's Davies Lab Publications:

  • Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS. Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. J Biol Chem. 2015 May 8;290(19):11865–11877
  • Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 2017 Oct;6(10):1137-1149.
  • Cushing EM, Sylvers KL, Chi X, Shetty SK, Davies BS. Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4–/–Gpihbp1–/– mice. J. Lipid Res. Jul 1;59(7):1230–1243
Photo of Emily Malcolm

Emily Malcolm Cushing
Graduate Student (2013-2018)

Originally from Arkansas, Emily received her B.S. in Chemistry and Biology from the University of Central Arkansas in 2007 and her M.S. in Chemistry from Georgia Tech in 2010.  She joined the Biochemistry program at the University of Iowa in 2012, and became the first graduate student to join the Davies lab in 2014. Emily defended her thesis "Regulation of Plasma Triglycerides by ANGPTL4 and GPIHBP1" in 2018. After graduating, Dr. Cushing began her postdoc in the lab of Alan Attie at the University of Wisconsin-Madison.

Emily's Davies lab publications:

  • Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS. Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. J Biol Chem. 2015 May 8;290(19):11865–11877
  • Cushing EM, Chi X, Sylvers KL, Shetty SK, Potthoff MJ, Davies BSJ. Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. Mol Metab. 2017 Jun 19;6(8):809–818.
  • Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 2017 Oct;6(10):1137-1149.
  • Cushing EM, Sylvers KL, Chi X, Shetty SK, Davies BS. Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4–/–Gpihbp1–/– mice. J. Lipid Res. Jul 1;59(7):1230–1243

 

Undergraduate Students

Grace

Grace Early

Undergraduate Student (2024-2026)

Portrait of Hattie Ruhland

Hattie Ruhland

Undergraduate Student (2025-2026)

Max

Max Mercer

Undergraduate Student (2023-2025)

Ethan

Ethan Hahlbeck

Undergraduate Student (2022-2024)

 Kaleb Bierstedt
Undergraduate Student (2021-2022)
 Gabe Ewert
Undergraduate Student (2019-2022)
 Hannah Johnson
Undergraduate Student (2019-2022)
Photo of Hannah Shows

Hannah Shows
Undergraduate Student (2013-2015)

Hannah joined the Davies’ lab at the end of her freshman year, becoming the first undergraduate to join the lab. Although Hannah never fulfilled her dream of studying triglyceride metabolism in live grizzly bears she did finish her degree in Biochemistry in December 2015. In the fall of 2016 she started graduate school at Wright State University, eventually joining the lab of Kate Excoffon.

Hannah's Davies Lab Publications:

  • Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS. Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. J Biol Chem. 2015 May 8;290(19):11865–11877
  • Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 2017 Oct;6(10):1137-1149
Photo of Alex Hjelmaas

Alex Hjelmaas
Undergraduate Student (2013-2015)

Alex joined the Davies lab at the beginning of his Junior year. While in the lab Alex was awarded an ICRU Summer Research Award and the H.G Wittman Scholar Award. Alex also promised that he would continued to work in the lab until the Cub won the World Series. Despite this promise, Alex graduated in Spring 2015 and then attended medical school at the University of Michigan. The Cubs did not win the World Series until November 2016. Alex you still owe us a year and a half of lab work.

Alex's Davies Lab Publications:

  • Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS. Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. J Biol Chem. 2015 May 8;290(19):11865–11877
  • Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 2017 Oct;6(10):1137-1149.
Photo of Emily Britt

Emily Britt
Undergraduate Student (2014-2017)

Emily joined the Davies lab at the beginning of her Sophomore year. In her time here, Emily was awarded a Rex Montgomery Biochemistry Scholarship, the H.G. Khorana Scholar Award from the Department of Biochemistry, and the Joseph E. and Ursil I. Callen Prize from the College of Liberal Arts and Sciences. After graduating with a BS in Biochemistry in the Spring of 2017, she started graduate school at the University of Wisconsin-Madison in the Nutritional Sciences PhD program. She joined the lab of Jing Fan.

Emily's Davies Lab Publications:

  • Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Mol Metab. 2017 Oct;6(10):1137-1149.
Photo of Ashley Segura

Ashley Segura
Undergraduate Student (2016-2019)

Ashley joined the Davies lab at the end of her Freshman year. She worked on experiments to quantify binding between lipases and their inhibitors. Her lab duties include keeping the graduate students up to date on current memes and dance moves. In her time here she was an IBA scholar and was awarded the Joseph E. and Ursil I. Callen Prize from the College of Liberal Arts and Sciences. After graduating with a BS in Biochemistry in the Spring of 2019, she started graduate school at the University of California Berkeley in the Molecular and Cellular Biology PhD program. She joined the lab of Roberto Zoncu.

Ashley's Davies Lab Publications:

  • Sylvers-Davie KL, Segura-Roman A, Salvi AM, Schache KJ, Davies BSJ. Angiopoietin-like 3 Inhibition of Endothelial Lipase Is Not Modulated by Angiopoietin-like 8. J. Lipid Res. 2021 Aug 27;62:100112
Photo of Emily Frankowski
Emily Frankowski
Undergraduate Student (2017-2019)
Photo of Dasha Kozlova
Dasha Kozlova
Undergraduate Student (2017-2021)
Photo of Derek Metzger
Derek Metzger
Undergraduate Student (2018-2019)