Research Interests

Our lab studies the regulation of plasma lipid and lipoprotein metabolism, with a particular interest in how delivery of fatty acids to peripheral tissues is regulated in both healthy and disease states. Dysregulated lipid metabolism is associated with a variety of metabolic diseases, including diabetes and cardiovascular disease. Lipids are trafficked in the bloodstream in lipoproteins including chylomicrons, VLDL, LDL, and HDL, and the metabolism of these lipoproteins is essential for maintaining lipid homeostasis.

The levels of lipids and lipoproteins in the blood are controlled in part by enzymes called lipases. For example, lipoprotein lipase hydrolyzes triglycerides in chylomicrons and VLDL, releasing fatty acids that are taken up by tissues for fuel, storage, or synthesis of more complex lipids. Another lipase, endothelial lipase, acts on the phospholipid shell of HDL and regulates HDL cholesterol levels.  Our lab studies how these lipase pathways are controlled, with a particular focus on the ANGPTL family of proteins. Three members of the ANGPTL family, ANGPTL3, ANGPTL4, and ANGPTL8 act to inhibit lipases. Moreover, human genetic studies have found that deficiency in and of these proteins protects against cardiovascular disease, prompting a push towards therapeutics that target these proteins. We are interested in how, where, and when ANGPTL proteins interact with lipases like lipoprotein lipase and endothelial lipase, and in how these interactions alter lipid homeostasis and might contribute to or protect against metabolic disease.

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Events

21st Annual Gene F. Lata Biochemistry Undergraduate Honors Symposium promotional image

21st Annual Gene F. Lata Biochemistry Undergraduate Honors Symposium

Tuesday, April 29, 2025 1:00pm to 4:30pm
Medical Education Research Facility
This symposium celebrates the research accomplishments of Biochemistry and Molecular Biology undergraduates and provides graduating seniors an opportunity to present their research results.Presenters for 2025 include:Adam Benmoussa (Maria Spies Laboratory)Carter Salz (Ernesto Fuentes Laboratory)Ryan Nagel (Ron Weigel Laboratory)Paige Wiebke (Lori Wallrath Laboratory)Max Mercer (Brandon Davies Laboratory)Zachary Darr (Lori Wallrath Laboratory)Morgan Linahon (Hans-Joachim Lehmler Laboratory)
Biochemistry and Molecular Biology Seminar: Dr. Kara Davis promotional image

Biochemistry and Molecular Biology Seminar: Dr. Kara Davis

Thursday, May 1, 2025 10:30am to 11:20am
Medical Education Research Facility
This event is open to the public."Understanding Cellular Predictors of Relapse in Acute Lymphoblastic Leukemia"Kara Davis, DOStanford UniversityFaculty Hosts: Miles Pufall, PhD and Jessica Zimmerman, MDDavis Lab | https://kldavislab.org/

Biochemistry and Molecular Biology Seminar: Dr. Douglas Kojetin

Thursday, May 8, 2025 10:30am to 11:20am
Medical Education Research Facility
This event is open to the public."TBA"Douglas Kojetin, PhDVanderbilt UniversityFaculty Host: Ernesto Fuentes, PhDKojetin Lab | https://www.kojetinlab.org/
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